Hydroxy Methionine Copper MHA-Cu SUSTAR
Product Information
Product name: Hydroxy Methionine Copper — Feed Grade
Molecular formula: C₁₀H₁₈O₆S₂Cu
Molecular weight: 363.9
CAS No.: 292140-30-8
Appearance: Light blue powder
Physicochemical Properties
|
Item |
Indicator |
|
Methionine hydroxy analogue, % |
≥ 78.0% |
|
Cu²⁺, % |
≥ 15.0% |
|
Arsenic(subject to As) mg/kg |
≤ 5.0 |
|
Plumbum (subject to Pb) mg/kg |
≤ 10 |
|
Water content % |
≤ 5.0 |
|
Fineness (425μm pass rate (40 mesh)), % |
≥ 95.0 |
Product Efficacy
1. Promotes antibacterial and anti-inflammatory functions, enhancing resistance to infections.
2. Promotes iron metabolism and hemoglobin synthesis, helping prevent anemia.
3. Enhances keratin formation, improving hair, feather, and skin condition.
4. Increases enzyme activity and energy efficiency, improving feed conversion ratio (FCR).
Product Applications
1) Broilers
When MMHACs (hydroxy methionine chelates of copper, zinc, and manganese) were added to broiler diets, results showed that—compared with traditional inorganic trace minerals—the inclusion of MMHACs significantly increased body weight and drumstick (thigh) muscle weight, improved copper digestibility, and did not exert any negative effects on gizzard or bone health.
Table 1 .Carcass processing weight (g/bird) and woody breast and breast white striping scores of broilers fed inorganic and methionine hydroxyl analogue chelated zinc, copper, and manganese dietary treatment sat day 42.
|
Item |
ITM |
M10 |
T125 |
M30 |
SEM |
P-Value |
|
Breast |
684 |
716 |
719 |
713 |
14.86 |
0.415 |
|
Thigh |
397 |
413 |
412 |
425 |
7.29 |
0.078 |
|
Drumstick |
320 |
335 |
332 |
340 |
4.68 |
0.058 |
|
Thigh and drumstick |
717 a |
748 ab |
745 ab |
765 b |
11.32 |
0.050 |
|
Fat pad |
32.3 |
33.1 |
33.4 |
35.5 |
1.59 |
0.546 |
|
Liver |
68.0 |
67.4 |
66.0 |
71.1 |
2.41 |
0.528 |
|
Heart |
18.8 |
18.6 |
19.2 |
19.2 |
0.68 |
0.898 |
|
Kidney |
9.49 |
10.2 |
10.6 |
10.6 |
0.51 |
0.413 |
Note: ITM: Inorganic trace mineral 110 ppm Zn as ZnSO4 16 ppm Cu as CuSO4 and120 ppm Mn as MnO per Ross 308 nutritional recommendations;
M10: Amounts of 40 ppm Zn 10 ppm Cu and 40 ppm Mn as chelate ;
T125: Inorganic trace mineral 110 ppm Zn as ZnSO4 and 120 ppm Mn as MnO per Ross 308 guidelines with 125 ppm Cu as tribasic copper chloride (TBCC);
M30 = 40 ppm Zn, 30 ppm Cu, and 40 ppm Mn as chelate. Values in the same row with different superscripts differ significantly (P < 0.05).
2) Swines
A study investigated the effects of partially replacing inorganic trace minerals with mineral methionine hydroxy analogue chelates (MMHAC) in sow diets on both sows and their piglets. Results showed that MMHAC supplementation reduced body weight loss in lactating sows, promoted piglet body weight gain at day 18, significantly enhanced skeletal muscle histone acetylation levels at birth, and downregulated the expression of multiple inflammation- and muscle development–related genes. Overall, MMHAC improved intestinal health and muscle development in piglets through epigenetic and developmental regulation, enhancing their growth potential.
Table 2 Supplemental effects of mineral methionine hydroxy analogue chelate in sow diets on expression of key mRNA related to jejunal inflammation in suckling piglet
|
Item
|
ITM |
CTM |
SEM |
P- value |
|
d 1 of lactation x 10-5 |
||||
|
IL-8 |
1344 |
1018 |
178 |
0.193 |
|
MUC2 |
5380 |
5511 |
984 |
0.925 |
|
NF-κB (p50) |
701 |
693 |
93 |
0.944 |
|
NF-κB (p105) |
1991 |
1646 |
211 |
0.274 |
|
TGF-b1 |
From 1991 |
1600 |
370 |
0.500 |
|
TNF-α |
11 |
7 |
2 |
0.174 |
| d 18 of lactation x 10-5 | ||||
|
IL-8 |
1134 |
787 |
220 |
0.262 |
|
MUC2 |
5773 |
3871 |
722 |
0.077 |
Note:Interleukin-8 (IL-8), mucin-2 (MUC2), nuclear factor-κB (NF-κB), transforming growth factor-1 (TGF-1), and tumor necrosis factor-α (TNF-α)
ITM = conventional inorganic sources of trace minerals (0.2% inclusion level in the diets)
CTM = 50:50 mineral methionine hydroxy analogue chelate and inorganic minerals (0.2% inclusion level in the diets)
3) Ruminants
In lactating dairy cows, replacing half of copper sulfate with hydroxy methionine copper significantly increased plasma copper concentration, improved the digestibility of neutral detergent fiber (NDF) and acid detergent fiber (ADF), and enhanced both milk yield and 4% fat-corrected milk production. These findings indicate that partially replacing copper sulfate with (HMTBA)₂-Cu in dairy cow diets is a more efficient nutritional strategy.
Table 3 Effects of methionine hydroxy Cu [(HMTBA)2-Cu] on the milk composition of cows
|
Item |
S |
SM |
M |
SEM |
P-value |
| DMI, kg/d |
19.2 |
20.3 |
19.8 |
0.35 |
0.23 |
| Milk yield, kg/d |
28.8 |
33.8 |
31.3 |
1.06 |
0.08 |
| Fat, % |
3.81 |
3.74 |
3.75 |
0.06 |
0.81 |
| Protein, % |
3.34 |
3.28 |
3.28 |
0.04 |
0.19 |
| Lactose, % |
4.48 |
4.35 |
4.43 |
0.05 |
0.08 |
| SNF, % |
8.63 |
8.84 |
8.63 |
0.05 |
0.33 |
| Fat yield, kg/d |
1.04 |
1.22 |
1.10 |
0.04 |
0.09 |
| Protein yield, kg/d |
0.92 |
0.92 |
0.90 |
0.03 |
0.72 |
| Lactose yield, kg/d |
1.23 |
1.23 |
1.21 |
0.04 |
0.45 |
| Urea N, mg/dL |
18.39 |
17.70 |
18.83 |
0.45 |
0.19 |
| 4% FCM, kg/d |
26.1 |
30.1 |
27.5 |
0.91 |
0.06 |
Treatments: S = Cu sulfate only: 12 mg of Cu provided by CuSO4 per kilogram of concentrate; SM = Cu sulfate and (HMTBA)2-Cu: 6 mg of Cu provided by CuSO4, and another 6 mg of Cu provided by (HMTBA)2-Cu per kilogram of concentrate; M = (HMTBA)2-Cu only: 12 mg of Cu provided by (HMTBA)2-Cu per kilogram of concentrate.
Usage and Dosage
Applicable species: Livestock animals
Usage and dosage: The recommended inclusion level per ton of complete feed is shown in the table below (unit: g/t, calculated as Cu²⁺).
|
Piglet |
Growing/Finishing Pig |
Poultry |
Cattle |
Sheep |
Aquatic Animal |
|
35-125 |
8-20 |
5-20 |
3-20 |
5-20 |
10-15 |
Packaging specification: 25 kg/bag, double-layer inner and outer bags.
Storage: Keep sealed in a cool, ventilated, and dry place. Protect from moisture.
Shelf life: 24 months.
Top Choice of International Grop
Sustar group has decades-long partnership with CP Group, Cargill, DSM, ADM,Deheus ,Nutreco,New Hope ,Haid,Tongwei and some other TOP 100 big feed company.
Our Superiority
A Reliable Partner
Research and development capabilities
Integrating the talents of the team to build Lanzhi Institute of Biology
In order to promote and influence the development of livestock industry at home and abroad, Xuzhou Animal Nutrition Institute , Tongshan District Government, Sichuan Agricultural University and Jiangsu Sustar, the four sides established Xuzhou Lianzhi Biotechnology Research Institute in December 2019.
Professor Yu Bing of Animal Nutrition Research Institute of Sichuan Agricultural University served as the dean, Professor Zheng Ping and Professor Tong Gaogao served as the deputy dean. Many professors of Animal Nutrition Research Institute of Sichuan Agricultural University helped the expert team to accelerate the transformation of scientific and technological achievements in the animal husbandry industry and promote the development of the industry.
As a member of the National Technical Committee for Standardization of Feed Industry and the winner of China Standard Innovation Contribution Award, Sustar has participated in drafting or revising 13 national or industrial product standards and 1 method standard since 1997.
Sustar has passed the ISO9001 and ISO22000 system certification FAMI-QS product certification, obtained 2 invention patents, 13 utility model patents, accepted 60 patents, and passed the "Standardization of intellectual property management system", and was recognized as a national-level new high-tech enterprise.
Our premixed feed production line and drying equipment are in the leading position in the industry. Sustar has high performance liquid chromatograph, atomic absorption spectrophotometer, ultraviolet and visible spectrophotometer, atomic fluorescence spectrophotometer and other major testing instruments, complete and advanced configuration.
We has more than 30 animal nutritionists, animal veterinarians, chemical analysts, equipment engineers and senior professionals in feed processing, research and development, laboratory testing, to provide customers with a full range of services from formula development, product production, inspection, testing, product program integration and application and so on.
Quality inspection
We provide test reports for each batch of our products, such as heavy metals and microbial residues. Each batch of dioxins and PCBS complies with EU standards. To ensure safety and compliance.
Assist customers to complete the regulatory compliance of feed additives in different countries, such as the registration and filing in the EU, USA, South America, Middle East and other markets.
Production Capacity
Main product production capacity
Copper sulfate-15,000 tons/year
TBCC -6,000 tons/year
TBZC -6,000 tons/year
Potassium chloride -7,000 tons/year
Glycine chelate series -7,000 tons/year
Small peptide chelate series-3,000 tons/year
Manganese sulfate -20,000 tons /year
Ferrous sulfate-20,000 tons/year
Zinc sulfate -20,000 tons/year
Premix (Vitamin/Minerals)-60,000 tons/year
More than 35 years history with five factory
Sustar group has five factories in China ,with annual capacity up to 200,000 tonns, covering totally 34,473 square meters，220 employees.And we’re an FAMI-QS/ISO/GMP certified company .
Customized Services
Customize Purity Level
Our company has a number of products have a wide variety of purity levels, especially to support our customers to do customized services, according to your needs. For example, our product DMPT is available in 98%, 80%, and 40% purity options; Chromium picolinate can be provided with Cr 2%-12%; and L-selenomethionine can be provided with Se 0.4%-5%.
Custom Packaging
According to your design requirements, you can customize the logo, size, shape, and pattern of the outer packaging
No one-size-fits-all formula? We tailor it for you!
We are well aware that there are differences in raw materials, farming patterns and management levels in different regions. Our technical service team can provide you with one to one formula customization service.
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