Hydroxy Methionine Manganese MHA-Mn SUSTAR
Hydroxy methionine manganese is the manganese salt of 2-hydroxy-4-(methylthio) butanoic acid. In 2010, Regulation (EC) No 1831/2003 of the European Parliament and of the Council approved hydroxy methionine and its manganese salt as feed additives. Mn-MHA not only provides the essential trace element manganese but also serves as a nutritional analogue of methionine. Its main benefits include promoting bone and cartilage development, enhancing antioxidant defenses, improving reproductive performance, and strengthening immunity. With high stability and bioavailability, Mn-MHA has become a cost-effective alternative to inorganic manganese salts in compound feeds, concentrates, and premixes.
Product Information
Product name: Manganese Hydroxy Methionine Analogue
Molecular formula: C10H18O6S2Mn
Molecular weight: 221.12
Appearance: Light brown or grayish-white powder
Physicochemical Properties
|
Item |
Indicator |
|
Methionine hydroxy analogue, % |
≥ 76.0 |
|
Mn2+, % |
≥ 14 |
|
Arsenic(subject to As), mg/kg |
≤ 5.0 |
|
Plumbum (subject to Pb), mg/kg |
≤ 10.0 |
|
Cadmium (subject to Cd), mg/kg |
≤ 5.0 |
|
Water content, % |
≤ 10 |
|
Fineness (425μm pass rate (40 mesh)), % |
≥ 95.0 |
Product Efficacy
1.Strong bones – Promotes cartilage formation and skeletal integrity.
2.Antioxidant defense – Core component of Mn-SOD, reducing oxidative stress.
3.Enhances nutrient absorption and energy utilization.
4.Better fertility & immunity – Promotes hormone synthesis, embryo health, and immune response.
Product Applications
1) Layers
In layer diets, replacing inorganic manganese and zinc with hydroxy methionine chelated manganese and zinc maintained production performance and egg quality while reducing trace mineral excretion, demonstrating efficient and eco-friendly characteristics. During the late laying period, it also tended to improve laying rate, daily egg output, and feed-to-egg ratio.
Note: 1: 80 mg/kg ZnSO₄, 60 mg/kg MnSO₄; 2: 20 mg/kg ZnSO₄, 15 mg/kg MnSO₄; 20 mg/kg Zn-MHA, 15 mg/kg Mn-MHA; 3: 40 mg/kg Zn-MHA, 30 mg/kg Mn-MHA. Different letters within the same color indicate significant differences among treatment groups (P < 0.05).
2) Growing–finishing pigs
In growing–finishing pigs, partial replacement (1/5–2/5) of inorganic trace minerals with MHA-M not only improved average daily gain and enhanced immune and antioxidant functions but also significantly reduced fecal excretion of Cu, Fe, Mn, and Zn.
Table 1 Effect of methionine hydroxyl analog chelated microminerals on immune function in growing–finishing pigs
| Item | ITM 1/5 | MHA-M 2/5 | MHA-M 3/5 | MHA-M 4/5 | MHA-M | MHA-M | SEM | P value |
| Serum g/L | ||||||||
| Day 35 | ||||||||
| IgA | 1.03c | 1.28ab | 1.19b | 0.80d | 0.98c | 1.40 a | 0.03 | <0.001 |
| IgG | 8.56c | 8.96ab | 8.94ab | 8.06d | 8.41 cd | 9.27 a | 0.07 | <0.001 |
| IgM | 0.84c | 0.92b | 0.91b | 0.75d | 0.81 cd | 1.00 a | 0.01 | <0.001 |
| Day 70 | ||||||||
| IgA | 1.28ab | 1.27ab | 1.35 a | 1.35 a | 1.12b | 0.86c | 0.03 | <0.001 |
| IgG | 8.98ab | 9.14 a | 8.97ab | 8.94ab | 8.42bc | 8.15c | 0.08 | <0.001 |
| IgM | 0.94 a | 0.91ab | 0.95 a | 0.95 a | 0.86b | 0.78c | 0.01 | <0.001 |
| Day 91 | ||||||||
| IgA | 1.13ab | 1.16ab | 1.14ab | 1.24 a | 1.01b | 1.03b | 0.02 | 0.012 |
| IgG | 9.32ab | 9.25ab | 9.25ab | 9.48 a | 8.81ab | 8.74b | 0.08 | 0.014 |
| IgM | 0.88ab | 0.90ab | 0.90ab | 0.93 a | 0.83b | 0.84b | 0.01 | 0.013 |
Note：Within a row, different superscripts mean significant difference (P < 0.05).
ITM, a basal diet with Cu, Fe, Mn, and Zn from sulfates providing 20, 100, 40, and 60 mg/kg; MHA-M, methionine hydroxyl analog chelated microminerals; SEM, standard error of mean.
3) Aquatic animals
Supplementing 30.69–45.09 mg/kg hydroxy methionine chelated manganese in the diet of Litopenaeus vannamei (Pacific white shrimp) significantly improved growth performance, antioxidant capacity, and immune function, and enhanced manganese deposition in tissues. The optimal level was 30.69 mg/kg, which increased antioxidant enzyme activity, improved lipid metabolism, and downregulated genes related to endoplasmic reticulum stress and apoptosis.
Note: Effects of different dietary Mn-MHA levels on Mn metabolism, antioxidant nonspecific immunity, endoplasmic reticulum stress, apoptosis and lipid metabolism in L. vannamei. Red arrows represent an increase, the blue arrow indicates descent.
Usage and Dosage
Applicable species: Livestock animals
Usage and dosage: The recommended inclusion level per ton of complete feed is shown in the table below (unit: g/t, calculated as Mn²⁺).
|
Pigs |
Growing/Finishing Pigs |
Poultry |
Cattle |
Sheep |
Aquatic animal |
|
10-70 |
15-65 |
60-150 |
15-100 |
10-80 |
20-80 |
Packaging specification: 25 kg/bag, double-layer inner and outer bags.
Storage: Keep sealed in a cool, ventilated, and dry place. Protect from moisture.
Shelf life: 24 months.
Top Choice of International Grop
Sustar group has decades-long partnership with CP Group, Cargill, DSM, ADM,Deheus ,Nutreco,New Hope ,Haid,Tongwei and some other TOP 100 big feed company.
Our Superiority
A Reliable Partner
Research and development capabilities
Integrating the talents of the team to build Lanzhi Institute of Biology
In order to promote and influence the development of livestock industry at home and abroad, Xuzhou Animal Nutrition Institute , Tongshan District Government, Sichuan Agricultural University and Jiangsu Sustar, the four sides established Xuzhou Lianzhi Biotechnology Research Institute in December 2019.
Professor Yu Bing of Animal Nutrition Research Institute of Sichuan Agricultural University served as the dean, Professor Zheng Ping and Professor Tong Gaogao served as the deputy dean. Many professors of Animal Nutrition Research Institute of Sichuan Agricultural University helped the expert team to accelerate the transformation of scientific and technological achievements in the animal husbandry industry and promote the development of the industry.
As a member of the National Technical Committee for Standardization of Feed Industry and the winner of China Standard Innovation Contribution Award, Sustar has participated in drafting or revising 13 national or industrial product standards and 1 method standard since 1997.
Sustar has passed the ISO9001 and ISO22000 system certification FAMI-QS product certification, obtained 2 invention patents, 13 utility model patents, accepted 60 patents, and passed the "Standardization of intellectual property management system", and was recognized as a national-level new high-tech enterprise.
Our premixed feed production line and drying equipment are in the leading position in the industry. Sustar has high performance liquid chromatograph, atomic absorption spectrophotometer, ultraviolet and visible spectrophotometer, atomic fluorescence spectrophotometer and other major testing instruments, complete and advanced configuration.
We has more than 30 animal nutritionists, animal veterinarians, chemical analysts, equipment engineers and senior professionals in feed processing, research and development, laboratory testing, to provide customers with a full range of services from formula development, product production, inspection, testing, product program integration and application and so on.
Quality inspection
We provide test reports for each batch of our products, such as heavy metals and microbial residues. Each batch of dioxins and PCBS complies with EU standards. To ensure safety and compliance.
Assist customers to complete the regulatory compliance of feed additives in different countries, such as the registration and filing in the EU, USA, South America, Middle East and other markets.
Production Capacity
Main product production capacity
Copper sulfate-15,000 tons/year
TBCC -6,000 tons/year
TBZC -6,000 tons/year
Potassium chloride -7,000 tons/year
Glycine chelate series -7,000 tons/year
Small peptide chelate series-3,000 tons/year
Manganese sulfate -20,000 tons /year
Ferrous sulfate-20,000 tons/year
Zinc sulfate -20,000 tons/year
Premix (Vitamin/Minerals)-60,000 tons/year
More than 35 years history with five factory
Sustar group has five factories in China ,with annual capacity up to 200,000 tonns, covering totally 34,473 square meters，220 employees.And we’re an FAMI-QS/ISO/GMP certified company .
Customized Services
Customize Purity Level
Our company has a number of products have a wide variety of purity levels, especially to support our customers to do customized services, according to your needs. For example, our product DMPT is available in 98%, 80%, and 40% purity options; Chromium picolinate can be provided with Cr 2%-12%; and L-selenomethionine can be provided with Se 0.4%-5%.
Custom Packaging
According to your design requirements, you can customize the logo, size, shape, and pattern of the outer packaging
No one-size-fits-all formula? We tailor it for you!
We are well aware that there are differences in raw materials, farming patterns and management levels in different regions. Our technical service team can provide you with one to one formula customization service.
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