1） Broiler chickens
Studies have shown that under heat stress conditions at 32 °C, the calcium salt of methionine hydroxy analog (HMTBa-Ca) improves feed intake, average daily gain, and muscle growth in broilers more effectively than DL-methionine (DLM). At the same time, it significantly enhances antioxidant capacity, reduces free radical levels, and improves redox status, thereby demonstrating superior performance in promoting production efficiency and alleviating oxidative stress.
Note: DLM refers to DL-methionine, and HMTBa-Ca refers to the calcium salt of hydroxy methionine analog. Different letters following data in the same column indicate significant differences among treatment groups (P < 0.05).
| Group | Final Body Weight (kg) | Average Daily Gain (g) | Average Daily Feed Intake (g) | Feed Conversion Ratio |
|
0.1%DLM |
2.25 ± 0.13a |
53. 61 ± 2. 99a |
122. 40 ± 4. 06a |
2.29 ± 0. 17b |
|
0.2%DLM |
2.37 ± 0. 14ab |
56. 41 ± 3. 38ab |
128. 24 ± 4. 22b |
2. 28 ± 0. 19b |
|
0.3%DLM |
2.39 ± 0. 15ab |
56. 85 ± 3. 63ab |
122. 65 ± 4. 83a |
2. 16 ± 0.11b |
|
0.1%HMTB-Ca |
2.38 ± 0. 18ab |
56. 61 ± 4. 22ab |
123. 16 ± 7. 07a |
2. 18 ± 0. 10b |
|
0.2%HMTB-Ca |
2.44 ± 0. 13b |
58. 01 ± 3. 03b |
130. 80 ± 4. 44b |
2. 26 ± 0. 17b |
|
0.3%HMTB-Ca |
2.57 ± 0. 11c |
61. 12 ± 2. 68c |
124. 93 ± 4. 92a |
2. 04 ± 0. 17a |
2） Pigs
Studies have found that supplementing piglet diets with one-eighth of DL-2-hydroxy-4-(methylthio)butanoic acid calcium (HMTBa-Ca) or with 65% of the dosage of DL-methionine (DLM) produced comparable improvements in growth performance, both significantly superior to methionine-deficient diets. No differences were observed among treatment groups in feed intake or mortality rate.
Table 1 Growth performance response to DL-methionine and DL-2 hydroxy-4-methylthio-butyrate acidfed at a ratio of 65:100 in nursery pigs
|
Variable |
Met-deficient |
HMTBCa |
65DLM |
SEM |
ANOVA, P- value |
|
BW, kg |
22.77b |
25.15a |
25.37a |
0.299 |
<0.001 |
|
ADG, g/d |
628b |
655a |
659a |
8.16 |
0.019 |
|
ADFl, g/d |
995 |
971 |
1010 |
14.00 |
0.164 |
|
G:F,g/g |
0.60b |
0.67a |
0.66a |
0.003 |
<0.001 |
|
Mortality,% |
0.00 |
0.00 |
0.06 |
0.036 |
0.376 |
3） Ruminants
In Holstein dairy cows, daily supplementation with 400 g of calcium salts of fatty acids and hydroxy methionine calcium significantly increased milk yield and lactose production. In primiparous cows, it also markedly improved reproductive performance, including higher conception rates and shorter calving intervals, without affecting body condition or body weight.
Table 2 Milk fat, protein and lactose yields (kg/day) and milk composition (g/kg) for cows receiving the control diet (C) or the lipid and methionine-supplemented diet (S)
|
Week of lactation |
C |
S |
S.E. |
|
|
Milk yield |
2-12 |
29.54a |
30.71b |
0.34 |
|
13-20 |
27.45c |
28.86d |
0.32 |
|
|
Fat yield |
2-12 |
1.17 |
1.19 |
0.01 |
|
13-20 |
1.10 |
1.10 |
0.01 |
|
|
Protein yield |
2-12 |
0.98 |
0.99 |
0.01 |
|
13-20 |
0.95 |
0.95 |
0.0 |
|
|
Lactose yield |
2-12 |
1.37c |
1.43d |
0.01 |
|
13-20 |
1.29c |
1.38d |
0.01 |
|
|
Fat concentration |
2-12 |
40.73 |
40.19 |
0.25 |
|
13-20 |
40.48c |
38.40d |
0.30 |
|
|
Protein concentration |
2-12 |
33.84c |
32.84d |
0.09 |
|
13-20 |
34.60c |
33.02d |
0.09 |
|
|
Lactose concentration |
2-12 |
46.36 |
46.36 |
0.08 |
|
13-20 |
6.71 |
46.76 |
0.09 |
|
Mean values with different superscripts within rows, are significantly different a,b(P < 0·05); c,d(P < 0·01).
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Post time: Mar-05-2026
